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The INTREPID Trial of Stereotactic Radiosurgery for Choroidal Neovascularization
The INTREPID Trial of Stereotactic Radiosurgery for Choroidal Neovascularization in AMD -
Peter K. Kaiser, M.D.

 

Revolutionary Treatment for AMD Launched  
Revolutionary Treatment for AMD Launched

 

BBC Radio Four:
In Touch Programme T. Jackson and Johnny Gathorne-Hardy discuss the Oraya Therapy - See more at: http://www.orayainc.com/physicians/#sthash.LelVABuU.dpuf 
BBC Radio Four:
In Touch Programme T. Jackson and Johnny Gathorne-Hardy discuss the Oraya Therapy

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Clinical Publications

Jackson, T. L., Chakravarthy, U. et al. “Stereotactic Radiotherapy for Neovascular Age-Related Macular Degeneration: 52-Week Safety and Efficacy Results of the INTREPID Study.” Ophthalmology Epub 2013 Mar 12.

Morales-Canton, V., Quiroz-Mercado, H., et al. “16 and 24 Gy Low-voltage X-ray Irradiation With Ranibizumab Therapy for Neovascular Age-Related Macular Degeneration: 12-Month Outcomes.” Am J Ophthalmol Epub 2013 Mar 13

Moshfeghi, A. A., Morales-Canton, V. M., et al. “16-Gy Low-Voltage X-ray Irradiation Followed by As-Needed Ranibizumab Therapy for Age-Related Macular Degeneration: 12-Month Outcomes of a ‘Radiation-First’ Strategy.” Br j Ophthalmol 96.10 (2012):1320-4. Epub 2012 Aug 15.

Canton, V. M., Quiroz-Mercado, H., et al. “24-Gy Low-Voltage X-Ray Irradiation with Ranibizumab Therapy for Neovascular AMD: 6-Month Safety and Functional Outcomes.” Ophthalmic Surg Lasers Imaging 43.1 (2012):20-4.

Moshfeghi, A. A., Canton, V. M., et al. “16-Gy Low-Voltage X-ray Irradiation Followed by As-Needed Ranibizumab Therapy for AMD: 6-Month Outcomes of a “Radiation-First” Strategy.” Ophthalmic Surg Lasers Imaging 42.6 (2011):460-67.

Canton, V. M., Quiroz-Mercado, H., et al. “16-Gy Low-Voltage X-Ray Irradiation with Ranibizumab Therapy for Neovascular AMD: 6-Month Safety and Functional Outcomes.” Ophthalmic Surg Lasers Imaging 42.6 (2011):468-73.

Evans, J. R., Sivagnanavel, V., et al. “Radiotherapy for Neovascular Age-Related Macular Degeneration.” Cochrane Database Syst Rev 5 (2010):CD004004.

Finger, P. T., Gelman, Y. P., et al. “Palladium-103 Plaque Radiation Therapy for Macular Degeneration: Results of a 7-Year Study.” Br J Ophthalmol 87.12 (2003):1497-503.

Jaakkola, A., Heikkonen, J., et al. “Strontium Plaque Brachytherapy for Exudative Age-Related Macular Degeneration: Three-Year Results of a Randomized Study.” Ophthalmology 112.4 (2005):567-73.

Moshfeghi, D., Moshfeghi, A. A., et al. “Radiation Therapy for Age-Related Macular Degeneration.” Advanced Ocular Care Jul/Aug (2010):33-7.

Moshfeghi, D. M., Kaiser, P. K., et al. “Stereotactic Low-Voltage X-Ray Irradiation for Age-Related Macular Degeneration.” Br J Ophthalmol 95.2 (2010):185-8.

Park, S. S., Daftari, I., et al. “Three-Year Follow-up of a Pilot Study of Ranibizumab Combined with Proton Beam Irradiation as Treatment for Exudative Age-Related Macular Degeneration.” Retina 2012 (Published ahead of print, Dec 16).

Petrarca, R. and Jackson, T., “Radiation Therapy for Neovascular Age-Related Macular Degeneration.” Clinical Ophthalmology 5 (2011):57-63.

Avila, M. P., Farah, M. E., et al. “Three-Year Safety and Visual Acuity Results of Epimacular 90strontium/90yttrium Brachytherapy with Bevacizumab for the Treatment of Subfovealchoroidal Neovascularization Secondary to Age-Related Macular Degeneration.” Retina 32.1 (2012):10-18.

Pre-Clinical and Technical Publications

Singh, R., E. Shusterman, et al. “Pilot Study of the Delivery of Microcollimated Pars Plana External Beam Radiation in Porcine Eyes: 270-Day Analysis” J Ophthalmol (2012):615214. Epub 2012 Jul 11

Singh, R. P., Shusterman, E. M., et al. “Evaluation of Microcollimated Pars Plana External Beam Radiation in Porcine Eyes” J Experiment Ophthalmol 2.3 (2011)

Hanlon, J., Firpo, M., et al. “Stereotactic radiosurgery for AMD: A Monte Carlo-based assessment of patient-specific tissue doses.” Invest Ophthalmol Vis Sci 52 (2011):2334-42.

Hanlon, J., Lee, C., et al. “Kilovoltage Stereotactic Radiosurgery for Age-Related Macular Degeneration: Assessment of Optic Nerve Dose and Patient Effective Dose.” Med Phys 36.8 (2009):3671-81.

Hasegawa, T., Kobayashi, T., et al. “Tolerance of the Optic Apparatus in Single-Fraction Irradiation Using Stereotactic Radiosurgery: Evaluation in 100 Patients with Craniopharyngioma.” Neurosurgery 66.4 688-94; discussion 694-5.

Miyamoto, H., Kimura, H., et al. “Effect of Focal X-Ray Irradiation on Experimental Choroidal Neovascularization.” Invest Ophthalmol Vis Sci 40.7 (1999):1496-502.

Taddei, P., Chell, E., et al. “Assessment of Targeting Accuracy of a Low-Energy Stereotactic Radiosurgery Treatment for Age-Related Macular Degeneration.” Phys Med Biol 55 2010:7037-7054.

Posters/Abstracts/White Papers/Presentations

Introini, U., Triolo, G., et al. (2013). IRay treatment of polypoidal choroidal vasculopathy: a pilot study. ARVO, Seattle, WA, USA.

Jackson, T. (2012). Responder Analysis of the INTREPID Study of Stereotactic Radiotherapy for Wet Age-Related Macular Degeneration. AAO, Chicago, IL, USA.

Jackson, T. (2012). Radiation for CNV: CABERNET/MERITAGE /INTREPID. AAO, Chicago, IL, USA.

Jackson, T. (2012). INTREPID Study: Stereotactic Radiotherapy for nvAMD. 12th EURETINA Congress, Milan, Italy

Moshfeghi, D. (2011). Treatment Durability and Vasculocidal Activity Following External Stereotactic Radiation for Wet AMD.Pan-American Association of Ophthalmology Congress 2011, Buenos Aires, Argentina.

Arnoldussen, M. E., Shusterman, M., et al. (2009). Quantitative Measurement of Retinal Structures Relative to the Geometric Axis of the Eye. ARVO, Ft. Lauderdale, FL, USA.

Arnoldussen, M. E., Shusterman, M., et al. (2010). Intraocular Pressure Measurement during Application of the Oraya I-Guide in Yucatan Mini-swine. ARVO, Ft. Lauderdale, FL, USA.

Chell, E., Arnoldussen, M. E., et al. (2011). Assessment of Motion Management in a Stereotactic Radiosurgical Device for the Treatment of Macular Degeneration. ARVO, Ft. Lauderdale, FL, USA.

Chell, E., Herron, M., et al. (2009). Dynamic Anthropomorphic Eye Phantoms for Targeting and Dose Verification of Novel Ophthalmic Radiosurgical Device. AAPM, Anaheim, CA, USA.

Firpo, M., Chell, E., et al. (2009). Dosimetry of a Novel Ophthalmic Stereotactic Radiosurgical Device. AAPM, Anaheim, CA, USA.

Firpo, M., Hanlon, J., et al. (2011). Simple Integrated Tissue-Air Ratio (SITAR): Determination of Depth Dose for a Narrow Field, Low Energy Ophthalmic Stereotactic Radiotherapy Device. AAPM, Vancouver, BC, Canada.

Hanlon, J., Chell, E., et al. (2011). Kilovoltage Stereotactic Radiosurgery for AMD: A More Complete Calculation of Effective Dose. AAPM, Vancouver, BC, Canada.

Moshfeghi, D., Pan, K. H., et al. (2009). Radiation Targeting and Dose Verification for Age-Related Macular Degeneration. ARVO, Ft. Lauderdale, FL, USA.

In the Press

Moshfeghi, A. “Radiation Therapy for Neovascular Age-related Macular Degeneration.” New Retina MD. Epub 2013 Apr.

King’s College Hospital. “King’s College Hospital First to Trial New Radiation Eye Treatment.” King’s College Hospital, NHS Foundation Trust 2010.

Haimovitch, L. (2009). OIS 2009 Report. Ophthalmology Innovations Summit, The Palace Hotel, San Francisco, CA.